AICAR 50mg

A chemical compound known as 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) is presented in this research-use-only format. AICAR is a well-studied pharmacological tool used in basic research to investigate metabolic and signaling pathways in mammalian cells.

Research Context

AICAR is a synthetic derivative of adenosine monophosphate (AMP), which is known to act as a selective activator of adenosine monophosphate-activated protein kinase (AMPK). AMPK is a central energy sensor in cells, regulating various metabolic processes, including glucose uptake, fatty acid oxidation, and protein synthesis. Due to its distinctive mechanism, AICAR has become a critical reagent in uncovering how cellular energy balance and metabolic homeostasis are regulated.

Research Overview

AICAR was first synthesized in the 1970s and has since been extensively used in preclinical research. It is often employed to model metabolic conditions such as insulin resistance and to explore the role of AMPK in diseases involving dysregulated metabolism, including type 2 diabetes, obesity, and cardiovascular disorders. The compound’s ability to bypass the endogenous synthesis pathway of AMP has made it particularly useful for acute and chronic experimental manipulations in cell culture and animal models.

Key Research Focus Areas

• Investigations into AMPK signaling pathways and their role in metabolic regulation.
• Study of insulin resistance and glucose metabolism using cellular and animal models.
• Exploration of effects on mitochondrial function and oxidative stress responses.
• Research into the potential applications of AMPK activators in therapeutic contexts for metabolic diseases.
• Investigation of cell cycle progression and proliferation in response to energy stress.

Safety and Compliance

While AICAR is a well-characterized research tool, it should always be handled with care as part of a controlled experimental setting. Exposure to high concentrations or improper handling may pose risks. Researchers are advised to follow standard laboratory safety protocols, including proper containment and disposal procedures. This product is intended exclusively for academic and institutional research purposes and is not intended for any therapeutic, diagnostic, cosmetic, or other non-research applications.

For research use only. Not for human or animal consumption.